Table 2.

Log-binomial univariate and multivariable model of the association between sociodemographic and clinical factors and chemoprevention use; multivariable model adjusted for age, race/ethnicity, family history, hormone replacement therapy use, and medical oncology referral

Characteristic		Univariate RR (95% CI)		p-value	Multivariable RR (95% CI)		p-value
Breast Histology	Atypical Hyperplasia	Reference
	Lobular Carcinoma in situ	1.62	(1.25 – 2.09)	0.0002	1.43	(1.16 – 1.76)	0.0009
	Ductal Carcinoma in situ	2.34	(1.89 – 2.90)	<.0001	1.54	(1.28 – 1.86)	<.0001
Age	<45 Years	0.63	(0.42 – 0.95)	0.0272	0.61	(0.42 – 0.87)	0.0069
	45–54 Years	Reference
	55–64 Years	1.29	(1.07 – 1.58)	0.0072	1.27	(1.10 – 1.47)	0.0012
	65–74 Years	1.26	(1.02 – 1.56)	0.0289	1.22	(1.05 – 1.43)	0.0116
	75+	0.89	(0.67 – 1.18)	0.4163	1.06	(0.85 – 1.31)	0.6119
Menopause	No	Reference
	Yes	1.47	(1.23 – 1.76)	<.0001
Race and Ethnicity	Non-Hispanic White	Reference
	Non-Hispanic Black	1.33	(1.06 – 1.67)	0.0153	0.99	(0.85 – 1.16)	0.9076
	Hispanic	1.25	(1.05 – 1.48)	0.0114	1.10	(0.99 – 1.22)	0.075
	Asian	1.42	(1.09 – 1.84)	0.0087	0.99	(0.82 – 1.18)	0.8942
	Other	0.49	(0.36 – 0.67)	<.0001	0.92	(0.72 – 1.19)	0.5403
Body Mass Index [BMI] (kg/m^2)	<18.5	0.63	(0.33 – 1.19)	0.1524
	18.5–24.99	Reference
	25–29.99	1.12	(0.93 – 1.34)	0.2303
	30+	1.25	(1.05 – 1.50)	0.0112
	Unknown	0.19	(0.11 – 0.32)	<.0001
Family History of Breast Cancer	No	Reference
	Yes	2.40	(2.09 – 2.76)	<.0001	0.98	(0.87 – 1.09)	0.6526
Hysterectomy	No	Reference
	Yes	1.06	(0.68 – 1.65)	0.7935
Comorbiditiesa	No	Reference
	DVT/PE/Stroke	0.71	(0.38 – 1.32)	0.2833
	Uterine Cancer	1.01	(0.39 – 2.62)	0.9758
HRT Useb	No	Reference
	Yes	2.85	(2.43 – 3.35)	<.0001	1.04	(0.90 – 1.19)	0.5941
Medical Oncology Referral	No	Reference
	Yes	6.14	(5.16 – 7.32)	<.0001	5.79	(4.80 – 6.98)	<.0001

^aDVT = Deep Vein Thrombosis, PE = Pulmonary Embolism

^bHRT = Hormone Replacement Therapy