Table 2.
Associations Between Peak VGRF, KAM, and VGRF Loading Rate and Biochemical Markers at Initial Presentation and Six Month Follow-Up Exams
| Peak Vertical Ground Reaction Force Limb Symmetry Index (vGRF LSI) | Vertical Ground Reaction Force Instantaneous Loading Rate Limb Symmetry Index (vGRF-LR LSI) | External Knee Adduction Moment Limb Symmetry Index (KAM LSI) | |||||||
|---|---|---|---|---|---|---|---|---|---|
| n | Association between vGRF LSI and Biomarker r (P value) | Partial Correlation Accounting for Walking Speed Partial r (P value) | n | Association between vGRF-LR LSI and Biomarker (P value) | Partial Correlation Accounting for Walking Speed Partial r (P value) | n | Association between KAM LSI and Biomarker (P value) | Partial Correlation Accounting for Walking Speed Partial r (P value) | |
| Initial Presentation IL-6 | 18 | −0.06 (0.83) | −0.02 (0.95) | 17 | −0.31 (0.23) | −0.21 (0.44) | 17 | −0.21 (0.41) | 0.04 (0.89) |
| Six-Month IL-6 | 18 | −0.19 (0.45) | −0.13 (0.59) | 17 | −0.20 (0.45) | −0.28 (0.29) | 17 | −0.42 (0.1) | −0.6 (0.01) |
| Initial Presentation C2C:CPII | 17 | −0.5 (0.04) | −0.24 (0.36) | 16 | −0.37 (0.16) | 0.27(0.64) | 16 | 0.15 (0.57) | 0.16 (0.57) |
| Six-Month C2C:CPII | 18 | −0.15 (0.56) | −0.16 (0.53) | 17 | 0.09 (0.73) | 0.11 (0.69) | 17 | 0.26 (0.31) | 0.21 (0.45) |
| Initial Presentation MMP-3 | 18 | −0.03 (0.91) | −0.21 (0.42) | 17 | −0.26 (0.32) | −0.12(0.66) | 17 | −0.64 (0.01) | −0.54 (0.03) |
| Six-Month MMP-3 | 18 | −0.4 (0.89) | −0.17 (0.52) | 17 | −0.60 (0.01) | −0.53 (0.04) | 17 | −0.67 (0.01) | −0.59 (0.02) |
MMP-3 - Matrix metalloproteninase-3, IL-6 - Interleukin- 6, C2C - collagen type-II cleavage product; CPII - collagen type-II C-propeptide