Table 4.
Meta-analyses results for the age coefficients on AIs, corrected for sex and ICV. The significance threshold was Bonferroni-adjusted to 0.007 for the seven comparisons. Cochran’s Q and Higgins’ I2 are the statistics for the heterogeneity of effects. Fail-safe N estimates are also given for the putamen. The statistically significant results are highlighted in bold
| Structure | Pooled effect | Standard error | P-value | Total N (datasets) | Cochran’s Q (p-value) | Higgins’ I2 | Fail-safe N |
|---|---|---|---|---|---|---|---|
| Nucleus accumbens | 2.1*10−6 | 2.1*10−4 | 0.99 | 12,073 (37) | 229.16(5.8*10−30) | 88.08 | 0 |
| Amygdala | -1.8*10−4 | 6.9*10−5 | 0.009 | 12,287 (38) | 74.75(2.3*10−4) | 54.07 | 0 |
| Caudate nucleus | 5.9*10−5 | 5.0*10−5 | 0.24 | 12,150 (36) | 148.03 (7.5*10−16) | 78.14 | 0 |
| Globus pallidus | -2.0*10−4 | 1.8*10−4 | 0.26 | 12,026 (35) | 151.14 (1.0*10−16) | 94.34 | 0 |
| Hippocampus | -1.0*10−4 | 4.0*10−5 | 0.012 | 12,212 (38) | 77.31(1.1*10−4) | 48.69 | 0 |
| Putamen | 1.5*10−4 | 4.35*10−5 | 4.0*10−4 | 12,042 (36) | 68.96 (5.3*10−4) | 59.34 | 85 |
| Thalamus | 1.5*10−4 | 8.4*10−5 | 0.071 | 12,202 (36) | 184.65 (3.0*10−22) | 90.91 | 0 |