Table 3.
PARP for Individual Risk Factors and Combinations of Factorsa
| Risk Factor | Breast Cancer, PARP (95% CI) | |
|---|---|---|
| Premenopausal | Postmenopausal | |
| 2 Risk Factors | ||
| Family history of breast cancer, breast density | 44.6 (41.3–47.9) | 32.2 (30.0–34.4) |
| History of benign breast biopsy, family history of breast cancer | 14.8 (13.3–16.3) | 16.0 (14.8–17.1) |
| History of benign breast biopsy, breast density | 43.5 (40.3–46.7) | 32.4 (30.8–34.0) |
| Breast density, BMI | NA | 43.3 (39.3–47.3) |
| Family history of breast cancer, BMI | NA | 29.1 (26.1–32.1) |
| History of benign breast biopsy, BMI | NA | 29.5 (24.4–34.2) |
| Nulliparous or age at first birth ≥30y, BMI | NA | 26.9 (23.9–29.8) |
| Nulliparous or age at first birth ≥30 y, family history of breast cancer | 16.6 (13.5–19.8) | 13.0 (11.4–14.5) |
| Nulliparous or age at first birth ≥30 y, history of benign breast biopsy | 15.0 (12.3–17.8) | 13.3 (11.8–14.9) |
| Nulliparous or age at first birth ≥30 y, breast density | 44.6 (41.1–48.1) | 30.0 (28.1–32.0) |
| 3 Risk Factors | ||
| Family history of breast cancer, history of benign breast biopsy, breast density | 48.3 (44.6–51.9) | 37.8 (35.9–39.7) |
| Family history of breast cancer, history of benign breast biopsy, nulliparous or age at first birth ≥30 y | 22.2 (19.8–24.6) | 20.3 (18.8–21.8) |
| Family history of breast cancer, history of benign breast biopsy, BMI | NA | 35.1 (30.2–40.0) |
| Family history of breast cancer, nulliparous or age at first birth ≥30 y, breast density | 49.4 (46.2–52.5) | 35.8 (33.9–37.6) |
| Family history of breast cancer, breast density, BMI | NA | 47.9 (45.1–50.7) |
| History of benign breast biopsy, nulliparous or age at first birth ≥30 y, breast density | 48.4 (45.1–51.7) | 35.9 (34.3–37.5) |
| History of benign breast biopsy, breast density, BMI | NA | 48.0 (44.7–51.4) |
| Family history of breast cancer, nulliparous or age at first birth ≥30 y, BMI | NA | 32.8 (29.9–35.8) |
| History of benign breast biopsy, nulliparous or age at first birth ≥30 y, BMI | NA | 33.2 (28.8–37.5) |
| Breast density, BMI, nulliparous or age at first birth ≥30 y | NA | 46.2 (42.5–49.9) |
| 4 Risk Factors | ||
| Family history of breast cancer, history of benign breast biopsy, breast density, nulliparous or age at first birth ≥30 y | 52.7 (49.1–56.3) | 41.0 (39.7–42.3) |
| Family history of breast cancer, history of benign breast biopsy, breast density, BMI | NA | 52.2 (49.0–55.4) |
| History of benign breast biopsy, nulliparous or age at first birth ≥30 y, breast density, BMI | NA | 50.7 (47.9–53.6) |
| Family history of breast cancer, nulliparous or age at first birth ≥30 y, breast density, BMI | NA | 50.6 (46.5–54.7) |
| Family history of breast cancer, nulliparous or age at first birth ≥30 y, history of benign breast biopsy, BMI | NA | 38.5 (36.4–40.7) |
| 5 Risk Factors | ||
| Family history of breast cancer, history of benign breast biopsy, nulliparous or age at first birth ≥30 y, breast density, BMI | NA | 54.7 (51.6–57.8) |
Abbreviations: BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); PARP, population-attributable risk proportion.
a
Family history of breast cancer, first-degree family history only; breast density, heterogeneously or extremely dense breasts with scattered fibroglandular densities as reference; BMI 25 or more.