. 2005 Feb 23;4:8. doi: 10.1186/1475-2891-4-8

Table 4.

Effects of control and soy foods on serum and urinary markers of bone metabolism

Measures	Control (n = 27)			Soy (n = 35)			Control vs Soy
	Baseline	6 months	Final	Baseline	6 months	Final	P values
							Trtmt	Time	Trtmt × Time
*Serum*

IGF-I (nmol/L)	17.9 ± 1.4^b	20.5 ± 1.4^a	20.2 ± 1.4^a	13.3 ± 1.2^c	16.8 ± 1.2^ab	16.8 ± 1.2^ab	0.023	< 0.001	0.693
IGFBP3 (ng/mL)	3833 ± 133	3934 ± 133	3904 ± 135	3442 ± 120^b	3751 ± 120^a	3622 ± 121^a	0.087	0.005	0.252
Osteocalcin (ng/mL)	8.3 ± 2.1^b	13.9 ± 2.1^a	16.2 ± 2.2^a	8.9 ± 1.9^b	17.4 ± 2.0^a	18.1 ± 2.0^a	0.365	< 0.001	0.671
BSAP (U/L)	19.8 ± 1.2^c	23.3 ± 1.2^b	25.3 ± 1.2^a	19.8 ± 1.1^c	22.6 ± 1.1^b	24.9 ± 1.1^a	0.796	< 0.001	0.818
ALP (U/L)	57.4 ± 3.0^c	65.9 ± 3.0^b	74.0 ± 3.1^a	56.6 ± 2.7^c	69.1 ± 2.7^b	74.3 ± 2.8^a	0.798	< 0.001	0.499
*Urine*
Dpd (nmol/mmol creatinine)	5.3 ± 0.4	5.3 ± 0.4	4.9 ± 0.4	5.2 ± 0.3	5.4 ± 0.3	5.1 ± 0.3	0.888	0.234	0.744

Values are least squares mean ± SE. IGF-I = insulin-like growth factor-I; IGFBP-3 = insulin-like growth factor binding protein-3; BSAP = bone-specific alkaline phosphatase; ALP = alkaline phosphatase; Dpd = deoxypyridinoline.

Within each row, values that do not share the same superscript letters are significantly (P < 0.05) different from each other.