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. 2017 Aug 2;7:7118. doi: 10.1038/s41598-017-07216-6

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of perinatal FM 550 exposure on adult behavior in the elevated plus maze (EPM). A significant difference between male and female controls was observed in both open arm entries and time in open arms (A and B; ^cp ≤ 0.05). In females, there was no significant effect of exposure for any of the observed endpoints. In males, open arm entries and time spent in the open arms was significantly reduced at the mid dose (A and B). No significant effect of exposure was observed for time in the closed arms (C). White bars indicate control groups, light gray low dose, dark grey mid dose, and black high dose. Graphs depict mean ± SEM (*p ≤ 0.05).