. 2017 Aug 3;4:42. doi: 10.3389/fsurg.2017.00042

Table 1.

International Gastric Cancer Linkage Consortium (IGCLC) criteria for HDGC.

Established criteria^a	Families in whom testing could be considered^a
Families with two or more patients with gastric cancer at any age, one confirmed DGC	Bilateral LBC or family history of 2 or more cases of LBC < 50
Individuals with DGC before the age of 40	A personal or family history of cleft lip/palate in a person with DGC
Families with diagnoses of both DGC and LBC (one diagnosis before the age of 50)	In situ signet ring cells and/or pagetoid spread of signet ring cells

^aIncluding first- and second-degree relatives.

HDGC, hereditary diffuse gastric cancer; DGC, diffuse gastric cancer; LBC, lobular breast cancer.