. 2017 Jul 26;6(2):146–155. doi: 10.7774/cevr.2017.6.2.146

Table 3. Reporting rate of adverse events following immunization by vaccine type from 2011 to 2016.

Vaccine	2011			2012			2013			2014			2015			2016
Vaccine	Doses	Cases	Cases/10⁵	Doses	Cases	Cases/10⁵	Doses	Cases	Cases/10⁵	Doses	Cases	Cases/10⁵	Doses	Cases	Cases/10⁵	Doses	Cases	Cases/10⁵
BCG^a)	431,302	97	22.5	476,893	58	12.2	439,812	96	21.8	438,124	87	19.9	440,825	78	17.7	408,834	85	20.8
HepB	2,366,019	32	1.4	2,315,340	25	1.1	2,150,090	16	0.7	2,082,593	9	0.4	2,048,318	18	0.9	2,037,218	18	0.9
DTaP	2,180,958	35	1.6	1,710,615	33	1.9	1,351,397	16	1.2	1,088,516	15	1.4	965,307	13	1.4	903,397	2	0.2
DTaP-IPV	153,203	1	0.7	713,233	14	2.0	1,042,166	14	1.3	1,217,408	16	1.3	1,269,984	22	1.7	1,283,915	20	1.6
Td	569,289	9	1.6	403,525	7	1.7	273,826	5	1.8	223,599	8	3.6	177,509	1	0.6	159,054	1	0.6
Tdap^b)	-	-	-	245,965	3	1.2	327,518	3	0.9	389,929	4	1.0	419,133	6	1.4	461,821	9	2.0
IPV	1,767,536	25	1.4	1,258,618	22	1.8	877,222	6	0.7	620,536	4	0.6	519,227	6	1.2	452,041	0	0
Hib^c)	-	-	-	-	-	-	1,924,190	18	0.9	1,800,824	17	0.9	1,761,388	23	1.3	1,714,675	20	1.2
PCV^d)	-	-	-	-	-	-	-	-	-	2,032,053	26	1.3	2,025,806	28	1.4	1,927,488	26	1.4
PPV23^e)	-	-	-	-	-	-	2,630,856	132	5.0	1,035,658	47	4.5	725,280	37	5.1	477,562	35	7.3
MMR	992,929	14	1.4	1,019,252	12	1.2	1,054,071	13	1.2	1,052,987	10	1.0	930,737	21	2.3	942,710	28	3.0
Var	505,211	13	2.6	528,924	7	1.3	556,410	5	0.9	546,967	4	0.7	553,904	14	2.5	582,429	14	2.4
HepA^f)	-	-	-	-	-	-	-	-	-	-	-	-	1,074,300	6	0.6	1,181,309	14	1.2
IJEV	1,874,654	22	1.2	2,04,04	23	1.2	2,120,176	15	0.7	1,738,627	28	1.6	1,530,334	16	1.1	1,623,809	32	2.0
LJEV^g)	-	-	-	-	-	-	-	-	-	266,999	1	0.4	310,155	0	0	274,396	2	0.7
HPV^h)	-	-	-	-	-	-	-	-	-	-	-	-	-	-	-	411,017	22	5.4
Influenza	8,458,902	40	0.5	9,271,184	31	0.3	9,622,884	38	0.4	10,298,776	44	0.4	11,426,015	55	0.5	12,576,100	65	0.5
KHF	199,467	0	0	169,360	0	0	134,560	0	0	118,636	0	0	115,693	0	0	97,558	1	1.0
ViCPS	185,016	2	1.1	158,406	0	0	91,354	0	0	71,483	0	0	67,060	0	0	82,218	1	1.2
Othersⁱ⁾	101	1	990.1	7,552	0	0	8,486	0	0	10,319	0	0	10,481	0	0	30,850	0	0
Total^j)	24,172,131	238	1.0	25,402,831	209	0.8	27,827,134	345	1.2	26,202,527	289	1.1	26,556,511	271	1.0	27,628,401	318	1.2

Values are presented as numbers.

BCG, bacillus Calmette-Guerin vaccine; HepB, hepatitis B vaccine; DTaP and Tdap, diphtheria, tetanus, and pertussis vaccine; IPV, inactivated polio vaccine; Td, tetanus diphtheria vaccine; Hib, haemophilus influenzae type b vaccine; PCV, pneumococcal conjugate vaccine; PPV23, 23-valent pneumococcal polysaccharide vaccine; MMR, measles, mumps, and rubella vaccine; Var, varicella vaccine; HepA, hepatitis A vaccine; IJEV, inactivated Japanese encephalitis virus vaccine; LJEV, live attenuated Japanese encephalitis virus vaccine; HPV, human papillomavirus vaccine; KHF, Korean hemorrhagic fever vaccine; ViCPS, Vi capsular polysaccharide vaccine for typhoid fever.

^a)Includes both intradermal and subcutaneous administration.

^b)Introduced to National Immunization Program (NIP) in 2012.

^c)Introduced to NIP in 2013.

^d)Introduced to NIP in 2014.

^e)Introduced to NIP in 2013.

^f)Introduced to NIP in 2015.

^g)Introduced to NIP in 2014.

^h)Introduced to NIP in 2016.

ⁱ⁾Includes non-NIP vaccines such as rotavirus, zoster, and meningococcal vaccine.

^j)The total number of reported adverse events each year is different with the sum of reported adverse events for each vaccine due to simultaneous administration of multiple vaccines.