Figure 8.

Four WT and four Egr-1−/− littermate adult mice were subjected to the open field test to measure general locomotion. The time spent moving, (A) was decreased in Egr-1−/− compared with WT mice and time spent at rest, (B) was increased. The Egr-1−/− moved a total distance that was less than WT mice, (C) and showed a decrease in the number discrete movement bouts, (D) the time spent in stereotypy movement, (E) and in discrete bouts of stereotypy, (F) when compared with WT mice. The same mice were subjected to the inverted grid test to measure strength and endurance in limb muscle. (G) Egr-1−/− 7458 show a significant decrease in limb strength and endurance compared to WT mice, as shown by the average latency in seconds that it took for the mice to fall from the inverted grid. p-values were obtained using Student’s t-tests. *(p ≤ 0.05); **(p ≤ 0.01); ***(p ≤ 0.001); ****(p ≤ 0.0001).