Table 7.
KEGG pathway enrichment analysis: normal vs. stress cardiomyopathy.
| KEGG pathway | Proteins | Enrichment ratio | Adj. p-value |
|---|---|---|---|
| Complement and coagulation cascades | C3, C4B, F2, A2M, F9, PLAT, F5 | 131.59 | <0.001 |
| Phagosome | MLB2, C3, THBS2, ITGB3, ITGB1 | 37.09 | <0.001 |
| Dilated cardiomyopathy | TNNI3, PRKACA, ITGB3, ITGB1 | 50.44 | <0.001 |
| Staphylococcus aureus infection | C3, C4B | 61.90 | <0.001 |
| Focal adhesion | THBS2, HGF, ITGB3, ITGB1 | 22.70 | <0.001 |
| Hypertrophic cardiomyopathy | TNNI3, ITGB3, ITGB1 | 41.02 | <0.001 |
| ECM–receptor interaction | THBS2, ITGB3, ITGB1 | 40.06 | <0.001 |
| Systemic lupus erythematosus | C3, C4B, ELANE | 25.04 | <0.01 |
| Malaria | HGF, THBS2 | 44.51 | <0.01 |
| Regulation of actin cytoskeleton | F2, ITGB3, ITGB1 | 15.98 | <0.01 |
| Arrhythmogenic right ventricular cardiomyopathy | ITGB3, ITGB1 | 30.67 | <0.01 |
| Leishmaniasis | C3, ITGB1 | 31.53 | <0.01 |
| Pathways in cancer | HGF, KLK3, ITGB1 | 10.44 | <0.01 |
| Axon guidance | Netrin-1, ITGB1 | 17.60 | <0.05 |
| Wnt signaling pathway | SFRP1, PRKACA | 15.30 | <0.05 |
| Alzheimer’s disease | APOE, GAPDH | 13.59 | <0.05 |
KEGG, Kyoto Encyclopedia of Genes and Genomes.