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. 2017 Aug 2;7:7133. doi: 10.1038/s41598-017-07325-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Role of EphA4-ephexin1-Cdk5 signaling, BDNF-TrkB signaling and synaptic protein in the antidepressant effect of rhynchophylline. (a) Schedule of social defeat stress (10 days), drug treatment, and brain sample collection. (b) Western blot analysis of EphA4 and p-EphA4 in the PFC, NAc, CA1, CA3, and DG of hippocampus. (c) Western blot analysis of ephexin1 and p-ephexin1 in the PFC, NAc, CA1, CA3, and DG of hippocampus. (d) Western blot analysis of p-Cdk5 (Tyr15)/Cdk5 in the PFC, NAc, CA1, CA3, and DG of hippocampus. The values are expressed as percentages relative to those in the control mice. The values represent the mean ± S.E.M. (n = 5 or 6). *P < 0.05 compared with the vehicle + stressed group. N.S.: not significant. (e): Western blot of BDNF in the PFC, NAc, CA1, CA3, and DG of hippocampus. (f): Western blot analysis of TrkB and p-TrkB in the PFC, NAc, CA1, CA3, and DG of hippocampus. (g): Western blot analysis of PSD-95 in the PFC, NAc, CA1, CA3, and DG of hippocampus. The values are expressed as percentages relative to those in the control mice. The values represent the mean ± S.E.M. (n = 5 or 6). *P < 0.05 compared with the vehicle + stressed group. N.S.: not significant.