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. 2017 Aug 2;7:7133. doi: 10.1038/s41598-017-07325-2

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Depression-like phenotype after bilateral injection of pAAV-PGK:: EphA4-Venus into the mPFC. (a) Schedule of pAAV vector injection, drug treatment, and behavioral tests. (b) Representative photographs of the injection sites and coronal brain sections in the mPFC. The success of AAV vector injection into the mPFC was confirmed by the presence of mRFP fluorescence. Scale bars = 200 μm (low-power images) and 20 μm (high-power images). (c) LMT. (d) TST. (e) FST. (f) SPT. The values represent the mean ± S.E.M. (n = 7). *P < 0.05 compared with the vehicle + EphA4 group. N.S.: not significant. (g) p-EphA4/EphA4 ratio in the PFC. (h) p-Ephexin1/Ephexin1 ratio in the PFC. (i) p-Cdk5(Tyr15)/Cdk5 ratio in the PFC. (j) BDNF in the PFC. (k) p-TrkB/TrkB ratio in the PFC. (l) PSD-95 in the PFC. The values represent the mean ± S.E.M. (n = 5 or 6). *P < 0.05 compared with the vehicle + EphA4 group. N.S.: not significant.