Table 1.
Anti-LCMV activity of PAP in CBA mice
| Disease Unset | |||||
| Days after inoculation with LCM Virus | |||||
| Survival (days) | Weight loss (grams) | Decreased mobility | Convulsions | Hair disheveled | |
| Vehicle | |||||
| Mouse #1* | <<1 | NA | 0 | NA | NA |
| Mouse #2* | <<1 | NA | 0 | NA | NA |
| Mouse #3* | <<1 | NA | 0 | NA | NA |
| Mouse #4 | 6 | 1.5 | 4.5 | 5.5 | 4.5 |
| Mouse #5 | 6 | 2 | 4.5 | 5.5 | 4.5 |
| Mouse #6 | 7 | 2 | 5 | 6 | 5 |
| Mouse #7 | 7 | 1.5 | 5 | 6 | 5 |
| Mouse #8 | 7 | 2.5 | 5 | 6 | 5 |
| Mouse #9 | 7 | 4.5 | 5 | 6 | 5 |
| Mouse #10 | 7 | 4.5 | 5 | 6 | 5 |
| Mouse #11 | 7 | 4.5 | 5 | 6 | 5 |
| Mouse #12 | 8 | 2 | 6 | 7 | 6 |
| Mouse #13 | 8 | 2.5 | 6 | 7 | 6 |
| Mouse #14 | 8 | 1 | 6 | 7 | 6 |
| Mouse #15 | 8 | 1.5 | 6 | 7 | 6 |
| Mouse #16 | 8 | 2 | 6 | 7 | 6 |
| Mouse #17 | 8 | 2 | 6 | 7 | 6 |
| Mouse #18 | 7 | 1.5 | 5 | 6 | 5 |
| Mouse #19 | 8 | 2 | 6 | 7 | 6 |
| Mouse #20 | 8 | 1.5 | 6 | 7 | 6 |
| PAP 0.25 mg/kg | |||||
| Mouse #1 | <<1 | NA | NA | NA | NA |
| Mouse #2 | <<1 | NA | NA | NA | NA |
| Mouse #3 | 6 | 1 | 4.5 | 5.5 | 5 |
| Mouse #4 | 7 | 1.5 | 5 | 6 | 5 |
| Mouse #5 | 8 | 1.5 | 6 | 7 | 5.5 |
| Mouse #6 | 21 | 0 | 10 | NO | NO |
| Mouse #7 | 21 | 0 | 10 | NO | NO |
| Mouse #8 | 21 | 0 | 10 | NO | NO |
| Mouse #9 | 21 | 0 | 10 | NO | NO |
| Mouse #10 | 21 | 0 | 10 | NO | NO |
*Mouse died after intracerebral injection; NA = not applicable, NO = not observed