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. 2017 Aug 2;7:7169. doi: 10.1038/s41598-017-05168-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of SCS A-β induces neuronal mtDNA depletion. (a) mtDNA copy number in SUCLA2- and nonTarget-shRNA-treated neurons. Nuclear DNA was used as the loading control. The expression levels of NDPK (b), DNA pol γ (c), Twinkle (d) and SSBP1 (e) in SUCLA2- and nonTarget-shRNA-treated neurons. The lower panels are representative immunoreactive bands. TOM40 was used as the loading control. The data were collected from 3 independent experiments.