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. 2017 Aug 2;7:7169. doi: 10.1038/s41598-017-05168-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Loss of SCS A-β disrupts neuronal mitochondrial dynamics. (a1) Dendritic mitochondrial length in SUCLA2- and nonTarget-shRNA-treated neurons. (a2) Analysis of the cumulative fraction of mitochondrial length. Data were collected from 400 mitochondria. (b1) Dendritic mitochondrial volume in SUCLA2- and nonTarget-shRNA-treated neurons. (b2) Analysis of the cumulative fraction of mitochondrial volume. Data were collected from 400 mitochondria. (c) Dendritic mitochondrial density in SUCLA2- and nonTarget-shRNA-treated neurons. Data were collected from 24 neurons per group. (d) are representative images of mitoDsred. Scale bar = 10 µm for upper panels, = 1 µm for enlarged mitochondria.