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. 2017 Jul 6;469(7):899–906. doi: 10.1007/s00424-017-2018-7

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© The Author(s) 2017

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 3 — “Canonical Wnt signaling” indicator mice demonstrate evident nuclear fluorescence in wild-type mice with UUO after 7 days; in contrast, DKK3 deficiency mice have a significant reduction in renal tubular epithelial fluorescence (AQP1: aquaporin 1 for proximal tubules, AQP2: aquaporin 2 for collecting ducts, TCF/LEF-H2B-GFPTr: reporter mouse with expression of green fluorescent protein when promoter regions of the Wnt dependent transcription factors TCF/LEF are activated by the canonical Wnt pathway. As nuclear fluorescence is evaluated unspecific background stain does not interfere)