Table 2.

Main and interaction effects of SORL1 and APOE on hippocampal connectivity

	Connectivity (sign)	BA	Parametric ANCOVA					Nonparametric permutation
			Coordinates (MNI)			Cluster size (voxels)	F value	Coordinates (MNI)			Cluster size (voxels)	P value
			x	y	z			x	y	z
SORL1	LHip and LMTG (positive)	21	−48	−3	−18	26	17.00	−51	−3	−15	34	0.0001
APOE	RHip and PCC (positive)	29	−6	−42	18	28	10.53	−6	−42	18	33	0.0009
	RHip and Pcu (positive)	23	12	−60	27	34	12.51	9	−63	27	41	0.0005
	RHip and RSMC (positive)	4	54	−15	51	130	15.42	48	−15	54	144	0.0001
	RHip and LSMC (positive)	4	−42	−30	66	37	11.40	−42	−30	66	64	0.0003
	LHip and Pcu (positive)	23	–	–	–	–	–	12	−57	27	58	0.0014
	LHip and sACC (positive)	25	3	3	−9	45	10.18	3	3	−9	71	0.0006
SORL1 × APOE	RHip and LIFG (negative)	45	−54	33	18	35	11.11	−51	39	0	40	0.0009

BA Brodmann area, Hip hippocampus, IFG inferior frontal gyrus, L left, MTG middle temporal gyrus, PCC posterior cingulate cortex, Pcu precuneus, R right, sACC subgenual anterior cingulate cortex, SMC sensorimotor cortex