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. 2017 Aug 2;7:7106. doi: 10.1038/s41598-017-06522-3

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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NREP, HIPK2, PRDM16, SMAD3 and their roles in the canonical TGF-β signalling pathway. The region-dependent accumulation of rare variants dataset was significantly enriched in the genes connected to the TGF-β pathway. Highlighted are the four genes contained in the dataset. Interactions were drawn using Pathvisio 3.2.4.