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. 2017 Aug 2;7:7110. doi: 10.1038/s41598-017-07672-0

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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FMT images and in vivo quantification of osteogenesis within the implanted scaffolds. The color scale indicates the mean fluorescent probe concentrations within the ROI, and the graph (A) shows the mean values of probe content (in pmol) calculated within groups and reported as percent of the mean value of the 2 wk group with cell-free scaffold. It is evident that a higher concentration of probe (OsteoSense 750) is present when the scaffolds contain hADSCs, at all time-points (B–D) when compared with cell-free scaffolds (E–G). In the graph A, the number into the circle indicates significant difference (P < 0.05) from the corresponding time-point, in weeks (same treatment group). The asterisk indicates significant difference (P < 0.05) from the other treatment group (same time-point).