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. 2017 Aug 2;7:7163. doi: 10.1038/s41598-017-07295-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Predicted PARTICLE consensus structure and triplex formation with one local enrichment at the WWOX tumor suppressor locus on chromosome 16. (A) Secondary structure minimum free energy (MFE) prediction of PARTICLE in human (left) and mouse (right) with LocARNA consensus pairing (centre; compatible base pairs are colored). (B) Schematics of the WWOX locus on human chromosome 16 and mouse chromosome 8 (upper, exons in blue boxes) and predicted triplex binding sites (yellow boxes) with PARTICLE (vertical lines, lower). (C) GENCODE hg19 assembly with PARTICLE triplex sites on plus (red) and minus (blue) genomic strands as identified by Triplexator v1.3.2. The genomic location of tumor suppressors MAT2A and WWOX are indicated. (D) Percentage of triplex binding sites (involving PARTICLE regions 1098–1114 nucleotides (white), 629–646 nucleotides (grey) and 624–644 nucleotides (black)) and (E) PARTICLE triplex frequency per megabase on all human chromosomes combined (All), chromosome 2 (Ch2) and 16 (Ch16) and within the WWOX locus. Human silhouette (id:47607240, Dreamstime.com).