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. 2017 Aug 2;7:7163. doi: 10.1038/s41598-017-07295-5

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Ingenuity® Analysis™ software (www.ingenuity.com) used in the analysis of genes with predicted PARTICLE triplex binding sites (Fig. S1 Triplex Domain Finder) associated with signaling pathways, molecular functions and diseases. (A) Graphical representation of genes with predicted PARTICLE triplex binding sites (pink) associated with the ERK 1/2 regulatory network. The predominance of triplexes within WWOX is shown in red. (B–D) Significantly associated signaling pathways (B), molecular functions (C) and diseases (D) involving genes with predicted PARTICLE triplexes. Pie chart (B) or histograms (C,D) of associated –log of the calculated p-value whereby a significant p value of p < 0.05 is equivalent to −log = 1.3.