TABLE 1 .

List of genes that are differentially expressed in the grf10Δ mutant

Group/GO term	FungiDB ID no.	Gene name	Function	Fold change	P value
Downregulated genes
Purine metabolism (GO ID no. 6189, 46040, 6188, 72522, 9127)	orf19.3870	ADE13	Adenylosuccinate lyase	−4.14	4.48E−7
	orf19.7484	ADE1	Phosphoribosylaminoimadazole succinocarboxamide synthetase	−3.06	4.66E−8
	orf19.492	ADE17	5-Aminoimidazole-4-carboxamide ribotide transformylase	−2.85	8.01E−7
	orf19.5061	ADE5,7	Phosphoribosylamine-glycine ligase and phosphoribosylformylglycinamidine cyclo-ligase	−2.50	1.91E−6
	orf19.5906	ADE2	Phosphoribosylaminoimadazole carboxylase	−2.28	6.97E−6
	orf19.6317	ADE6	5-Phosphoribosylformyl glycinamidine synthetase	−1.97	9.74E−6
One-carbon metabolism	orf19.5750	SHM2	Cytoplasmic serine hydroxymethyltransferase	−3.48	1.50E−8
	orf19.5838	SER2	Ortholog(s) has phosphoserine phosphatase activity	−2.48	4.58E−6
	orf19.3810	MTD1	Ortholog(s) has methylenetetrahydrofolate dehydrogenase (NAD+) activity	−3.52	1.36E−6
	orf19.1117		Protein similar to Candida boidinii formate dehydrogenase	−3.69	5.00E−8
	orf19.1774		Predicted formate dehydrogenase	−4.51	8.99E−8
Iron metabolism	orf19.1932	CFL4	C terminus similar to ferric reductases	−3.89	1.12E−8
	orf19.1930	CFL5	Ferric reductase	−3.02	1.09E−6
Transcription	orf19.5338	GAL4	Zn(II)2 Cys6 transcription factor; involved in control of glycolysis	−2.03	4.66E−6
Miscellaneous	orf19.4025	PRE1	Putative β4 subunit of 20S proteasome	−40.42	1.23E−10
	orf19.4028	RER2	cis-Prenyltransferase involved in dolichol synthesis	−12.76	1.47E−8
	orf19.6570	NUP	Nucleoside permease; transports adenosine and guanosine	−7.15	1.65E−8
	orf19.1788	XKS1	Putative xylulokinase	−5.29	8.37E−9
	orf19.4024	RIB5	Putative riboflavin (vitamin B2) synthase	−4.48	7.32E−8
	orf19.4394		Protein of unknown function	−4.24	3.89E−8
	orf19.4814		Uncharacterized	−2.96	2.15E−7
	orf19.3222		Predicted vacuolar protein	−2.62	4.46E−7
	orf19.300	AIP2	Putative actin-interacting protein; S. cerevisiae ortholog is d-lactate dehydrogenase	−2.41	8.58E−8
	orf19.4441		Ortholog(s) involved in initiation of DNA replication	−2.16	2.97E−7
	orf19.1344		Protein of unknown function	−2.10	2.54E−6
Upregulated genes
Cell adhesion and biofilm formation (GO ID no. 7155, 22610, 42710, 44011, 51703)	orf19.3548.1	WH11	White-phase yeast transcript	10.64	1.07E−8
	orf19.3160	HSP12	Heat shock protein	3.85	1.48E−7
	orf19.4216		Putative heat shock protein	3.64	1.88E−7
	orf19.2121	ALS2	ALS family protein; role in adhesion and biofilm formation	3.64	1.70E−6
	orf19.4555	ALS4	Glycosylphosphatidylinositol-anchored adhesin; roles in adhesion and germ tube induction	3.47	2.37E−7
	orf19.5437	RHR2	Glycerol 3-phosphatase; roles in osmotic tolerance	3.11	3.16E−6
	orf19.508	QDR1	Putative antibiotic resistance transporter	2.19	1.34E−5
	orf19.4477	CSH1	Aldo-keto reductase; role in fibronectin adhesion and cell surface hydrophobicity	2.11	2.51E−5
	orf19.1258		Adhesin-like protein	2.35	2.15E−6
	orf19.2475	PGA26	GPI-anchored adhesin-like protein of cell wall; role in cell wall integrity	2.00	2.36E−6
Miscellaneous	orf19.1868	RNR22	Putative ribonucleoside-diphosphate reductase	4.27	1.10E−7
	orf19.2531	CSP37	Cell wall protein, stationary-phase enriched, GlcNAc-induced	3.58	9.37E−8
	orf19.2633.1		Uncharacterized	3.23	9.14E−8
	orf19.1847	ARO10	Aromatic decarboxylase; catabolic alcohol synthesis	3.04	1.65E−7
	orf19.2048		Protein of unknown function	3.00	1.25E−6
	orf19.1863		Predicted Rho guanyl-nucleotide exchange factor activity	2.69	1.34E−5
	orf19.842	ASR3	Adenylyl cyclase and stress-responsive protein	2.50	4.13E−8
	orf19.3803	MNN22	α-1,2-Mannosyltransferase	2.50	2.30E−7
	orf19.125	EBP1	NADPH oxidoreductase	2.49	1.30E−6
	orf19.1862		Possible stress protein	2.36	1.51E−5
	orf19.251	GLX3	Glutathione-independent glyoxalase	2.36	2.52E−6
	orf19.3061.1		Ortholog of S. cerevisiae proteins Rps22A and Rps22B	2.32	1.22E−5
	orf19.5620		Protein of unknown function	2.24	1.38E−6
	orf19.1473		2-Hydroxyacid dehydrogenase domain-containing protein	2.20	2.85E−5
	orf19.1149	MRF1	Putative mitochondrial respiratory protein	2.19	2.69E−6
	orf19.4003	TIP20	Possibly involved in retrograde transport between Golgi apparatus and endoplasmic reticulum	2.01	3.78E−6
	orf19.1152		Protein of unknown function; induced in core stress response	2.01	1.06E−5
	orf19.6816		Putative xylose and arabinose reductase	2.00	5.98E−7
	orf19.2769		Putative protease B inhibitor	2.00	3.17E−6
	orf19.2047		Putative protein of unknown function; Hap43p-repressed gene	2.00	1.04E−5
	orf19.1691		S. cerevisiae ortholog is cytochrome c oxidase subunit	2.00	1.54E−5