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. 2005 Feb 3;24(5):1021–1032. doi: 10.1038/sj.emboj.7600570

Figure 10.

Figure 10

A model of how FHL2 regulates FOXO1 activity by SIRT1-mediated deacetylation. Active FOXO1 suppresses prostate tumorigenesis by inhibiting cell cycle progression and by inducing apoptosis. FOXO1 activation in prostate cancer cells requires acetylation at yet to be defined sites. These sites are essential for its modulation of gene expression by both direct DNA binding and ‘tethering'. FHL2 promotes prostate tumorigenesis by serving as an adaptor that couples SIRT1 and FOXO1 and thus inhibits FOXO1 action in prostate cells.