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. 2005 Feb 10;24(5):985–996. doi: 10.1038/sj.emboj.7600571

Figure 5.

Figure 5

XRap2 regulates the steady-state levels of β-catenin. (A) XRap2 MO (40 ng) decreases the levels of exogenous myc-β-catenin expressed from injected RNA (100 pg) in animal cap cells. (B) An increase in the level of β-catenin induced by XWnt8 (20 pg) is impeded by XRap2 MO. (C–G) XRap2 is required for the nuclear accumulation of endogenous β-catenin in animal cap cells (AC). (C) Uninjected control AC, (D) XRap2-injected AC, (E) XWnt8-injected AC, (F) AC injected with XWnt8 and Co MO and (G) AC injected with XWnt8 and XRap2 MO. Four-cell stage embryos were injected into the animal region with the indicated reagents (XRap2 RNA, 150 pg; XWnt8 RNA, 2 ng; XRap2 MO, 40 ng; Co MO, 40 ng). Animal caps dissected from late blastulae were stained with anti-β-catenin antibody.