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. Author manuscript; available in PMC: 2017 Aug 3.
Published in final edited form as: Neurobiol Learn Mem. 2016 Apr 23;131:201–206. doi: 10.1016/j.nlm.2016.04.009

Figure 1. OFC and BLA neurons respond differentially to a reversal in contingencies.

Figure 1

During initial training (pre-reversal; left panel) both OFC and BLA respond to cues predicting a rewarding outcome. However, when contingencies are reversed (post-reversal; right panel) these neuronal responses diverge. Specifically, the BLA neurons which were encoding the previously reward-predictive outcome now switch to start responding to now reward-predictive cue. In contrast, only about 20% of OFC neurons reverse their preference (Schoenbaum et al., 2003). Instead, a new population of neurons that were previously not cue-selective begin responding to the new contingency.