Table 2.
The 10 most significant canonical pathways regulated by AOM/DSS-induced tumors compared to normal colonic tissue in Control group. Genes in bold are down-regulated in tumors.
| Canonical Pathways | −log (p value) | Ratio | Target genes |
|---|---|---|---|
| Hepatic Fibrosis / Hepatic Stellate Cell Activation | 19.8 | 50/187 (0.267) | CCR5,COL9A3,MMP13,COL8A1,IL1R2,TGFB1,LA MA1,SERPINE1,PDGFRB,TNFRSF11B,IL4R,COL4 A1,MYH14,MMP2,IGFBP5,PDGFB,MYL7,MYL9,A CTA2,IL10RA,COL6A5,TNF,CCR7,COL7A1,IGFBP 4,ICAM1,FN1,IL1RL1,EGF,CCL5,COL4A2,MYH11, PDGFC,COL15A1,PGF,COL1A2,NGFR,PDGFRA,L BP,TNFRSF1B,COL18A1,VCAM1,COL5A2,COL12 A1,FGF1,COL1A1,COL5A3,IL1B,EDNRA,MMP9 |
| Atheroscleros is Signaling | 13.9 | 34/125 (0.272) | APOE,ICAM1,APOB,MMP3,PLA2G10,CMA1,MMP 13,ALOX12,PLA2G7,PDGFC,PRDX6,COL1A2,LYZ ,Pla2g2a,TGFB1,COL18A1,PLA2G12A,ALOX15,V CAM1,CXCR4,PLA2G3,F3,PDGFB,TPSAB1/TPSB 2,SELPLG,COL1A1,ITGB2,COL5A3,ALB,SELP,IL1 B,TNF,MMP9,CLU |
| Granulocyte Adhesion and Diapedesis | 13.1 | 40/179 (0.223) | MMP7,ICAM1,MMP3,CLDN15,IL1RL1,MMP14,MM P13,CCL22,CCL5,Cxcl9,IL1R2,CLDN4,SDC2,CCL 28,NGFR,CXCL14,MMP11,TNFRSF1B,MMP12,Ccl 6,MMP17,TNFRSF11B,VCAM1,CXCR4,PF4,MMP1 0,THY1,MMP2,CXCL6,SELPLG,ITGB2,CXCL16,IT GAM,SELP,CDH5,CLDN8,IL1B,TNF,MMP9,HSPB1 |
| LPS/IL-1 Mediated Inhibition of RXR Function | 12.9 | 45/224 (0.201) | GAL3ST2,APOE,CYP3A7,CHST4,GSTM5,IL1RL1, ABCC2,CYP2C9,ABCG1,HMGCS2,SOD3,ABCA1, CHST2,IL1R2,GSTT2/GSTT2B,MAOB,ALDH1A1, ACSBG1,ALDH1A3,Gstm3,NGFR,PPARGC1B,CH ST11,FABP5,LBP,TNFRSF1B,ALDH6A1,TNFRSF 11B,GSTA3,GSTM1,ALDH1B1,ABCB1,MGST1,SU LT1C2,CHST12,Sult1d1,SULT2B1,HS3ST3B1,FA BP2,ALDH1A2,IL1B,ABCC3,TNF,SULT1B1,MAO A |
| Agranulocyte Adhesion and Diapedesis | 11.5 | 39/190 (0.205) | MMP7,ICAM1,FN1,MMP3,CLDN15,MMP14,MMP1 3,CCL22,MYH11,CCL5,Cxcl9,CLDN4,CCL28,CXC L14,MMP11,ACTG2,MMP12,Ccl6,MMP17,ACTA1, VCAM1,CXCR4,PF4,MYH14,MMP10,MMP2,CXCL 6,SELPLG,MYL7,MYL9,ITGB2,CXCL16,SELP,CDH 5,CLDN8,ACTA2,IL1B,TNF,MMP9 |
| Xenobiotic Metabolism Signaling | 7.73 | 41/274 (0.15) | GAL3ST2,CYP3A7,CHST4,GSTM5,CAMK1D,ABC C2,CYP2C9,SOD3,CHST2,HMOX1,GSTT2/GSTT2 B,MAOB,CES1,ALDH1A1,ALDH1A3,Gstm3,Ugt1a 7c,CHST11,PRKCE,NOS2,PRKD1,ALDH6A1,GST A3,GSTM1,ALDH1B1,ABCB1,MGST1,SULT1C2,U GT2B10,CHST12,Sult1d1,SULT2B1,Ces1e,HS3S T3B1,PRKCD,ALDH1A2,IL1B,ABCC3,TNF,SULT1 B1,MAOA |
| Leukocyte Extravasation Signaling | 7.69 | 34/204 (0.167) | RAC2,MMP7,ICAM1,MMP3,CLDN15,MMP14,MMP 13,CLDN4,CYBA,CYBB,PRKCE,MMP11,ACTG2,M MP12,PRKD1,MMP17,ACTA1,VCAM1,CXCR4,TH Y1,MMP10,PLCG1,MMP2,NCF4,SELPLG,ITGB2,N CF1,ITGAM,EDIL3,CDH5,CLDN8,ACTA2,PRKCD, MMP9 |
| Role of Macrophages , Fibroblasts and Endothelial Cells in Rheumatoid Arthritis | 7.43 | 43/302 (0.142) | FZD10,SOCS3,TCF4,FN1,ICAM1,MMP3,IL1RL1,L TB,MMP13,WNT6,CCL5,PDGFC,FCGR1A,CCND1, PGF,PLCD1,IL1R2,WIF1,PLCE1,TGFB1,DKK3,NG FR,TLR7,DKK2,PRKCE,TNF RSF1B,NOS2,FCGR3A/FCGR3B,PRKD1,TNFRSF 11B,ADAMTS4,VCAM1,PLCG1,CREB3L4,PDGFB, TLR2,PRKCD,Tlr13,IL1B,LEF1,TNF,Tcf7,WNT5A |
| Complement System | 7 | 13/38 (0.342) | C1R,C4A/C4B,ITGB2,SERPING1,ITGAM,C3,C1QA ,C1QC,CFH,C1QB,C3AR1,C2,ITGAX |
| Axonal Guidance Signaling | 6.9 | 54/440 (0.123) | RAC2,ADAMTS8,BMP4,MMP13,WNT6,ADAMTS2, ADAM8,PLCE1,CFL2,PTCH2,PRKD1,ADAMTS4,T UBB3,PAPPA,MMP2,RAC3,PDGFB,MYL7,MYL9,A DAMTS6,ADAM12,PRKCD,EPHA2,FZD10,ADAMT S7,MMP7,BMP3,EGF,PDGFC,ROBO1,SEMA4C,P GF,TUBB2B,PLCD1,SDC2,NGFR,PRKCE,PLXNB1 ,MMP11,TUBB4A,SEMA4A,SEMA3F,BMP1,GNG4, PLXNC1,CXCR4,MMP10,PLCG1,PLXND1,SEMA4 G,BMP7,MMP9,SEMA7A,WNT5A |