Table 1.
Results of the gene-based analysis in the combined sample, and the respective p-values in the subsamples. Genes with puncorrected < 1.0 × 10−4 are shown. If a variant was located within a region shared by more than one gene, the variant was assigned to all of the respective genes.
| Gene | Position (hg18) | p-Value in the Combined Sample (2841 Cases, 3684 Controls) | p-Value in the ACP + ALC Subsample (1510 Cases, 1750 Controls) | p-Value in the AD Subsample (1331 Cases, 1934 Controls) |
|---|---|---|---|---|
| Alcohol Dehydrogenase 1B (ADH1B) | chr4: 100426552-100481581 | 1.209 × 10−6 | 0.68776 | 6.5258 × 10−10 |
| Family with Sequence Similarity 83 Member D (FAM83D) | chr20: 36968369-37035117 | 4.2443 × 10−6 | 0.0070016 | 0.34143 |
| Alcohol Dehydrogenase 1C (ADH1C) | chr4: 100456672-100512940 | 9.9601 × 10−6 | 0.86648 | 8.5406 × 10−10 |
| Zinc finger protein 697 (ZNF697) | chr1: 119943523-120011913 | 2.3488 × 10−5 | 0.0011435 | 0.0087101 |
| Ras Homolog Family Member T2 (RHOT2) | chr16: 638134-684172 | 3.006 × 10−5 | 0.025274 | 0.00029276 |
| Crystallin Zeta (CRYZ) | chr1: 74923772-74991315 | 3.0976 × 10−5 | 0.051974 | 0.00084007 |
| X-ray repair cross complementing 5 (XRCC5) | chr2: 216662378-216799248 | 3.4649 × 10−5 | 0.27561 | 2.7093 × 10−5 |
| COX14 Cytochrome C Oxidase Assembly Factor (COX14) | chr12: 48772167-48820501 | 3.7703 × 10−5 | 0.0017051 | 0.0044189 |
| Rhomboid, Veinlet-Like 1 (RHBDL1) | chr16: 646076-688268 | 4.5926 × 10−5 | 0.026591 | 0.00033002 |
| LOC440330 (LOC440330) | chr16: 648519-689772 | 4.5926 × 10−5 | 0.026591 | 0.00033002 |
| STIP1 homology and U-box containing protein 1 (STUB1) | chr16: 650116-692769 | 4.5926 × 10−5 | 0.026591 | 0.00033002 |
| Jumonji domain containing 8 (JMJD8) | chr16: 651668-694440 | 4.62 × 10−5 | 0.026732 | 0.00035589 |
| WD Repeat Domain 24 (WDR24) | chr16: 654703-700401 | 4.62 × 10−5 | 0.026732 | 0.00035589 |
| F-Box and Leucine-Rich Repeat Protein 16 (FBXL16) | chr16: 662503-715809 | 4.62 × 10−5 | 0.026732 | 0.00035589 |
| Olfactomedin Like 2A (OLFML2A) | chr9: 126559258-126636982 | 4.8774 × 10−5 | 0.00044653 | 0.015794 |
AD: Alcohol dependence; ACP: Chronic alcoholic pancreatitis; ALC: Alcohol-related liver cirrhosis.