Table 1. Descriptive Results of the HDX-MS Analysis of Hemoglobin and IgG4Δhinge with An-PEP or Pepsin.
Hemoglobin | ||||||||
---|---|---|---|---|---|---|---|---|
unique
peptides |
sequence coverage |
redundancy |
||||||
α subunit | β subunit | total | α subunit | β subunit | total | α subunit | β subunit | |
An-PEP | 30 | 8 | 38 | 99 | 92 | 96 | 4 | 1.7 |
pepsin | 13 | 14 | 27 | 89 | 99 | 95 | 2.8 | 2.6 |
IgG4Δhinge | ||||||||
---|---|---|---|---|---|---|---|---|
unique
peptides |
sequence coverage |
redundancy |
||||||
light chain | heavy chain | total | light chain | heavy chain | total | light chain | heavy chain | |
An-PEP | 19 | 69 | 88 | 88 | 92 | 91 | 2.1 | 3.5 |
pepsin | 24 | 75 | 99 | 100 | 90 | 93 | 3.2 | 4.3 |