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. Author manuscript; available in PMC: 2018 May 17.
Published in final edited form as: ACS Chem Neurosci. 2017 Apr 13;8(5):943–954. doi: 10.1021/acschemneuro.7b00026

Figure 4. Schematic depicting use of transgenic mice to selectively excise SERT from the peripheral sympathoadrenal system or central serotonergic neurons.

Figure 4

In the “floxed” SERT mouse, SERT is expressed in both central serotonergic neurons and adrenal chromaffin cells (depicted by blue shading). Crossing these mice with Cre driver lines provides a strategy to selectively excise SERT in a tissue specific manner. For example, ePet-Cre drives expression of Cre and excision of SERT in serotonergic neurons of the CNS but not in adrenal chromaffin cells. Conversely, using TH-Cre will result in excision of SERT in the adrenal chromaffin cells but not in CNS raphe neurons.