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. 2017 Jun 26;7(6):e013431. doi: 10.1136/bmjopen-2016-013431

Table 2.

Cox proportional hazards models analysis for associations between baseline hs-cTnT levels and outcomes

HR (95% CI)
Group 1
<3.00 ng/L
Group 2
3.0–6.21 ng/L
Group 3
6.22–<14 ng/L
Group 4
≥14 ng/L
No  679 324 324 172
MACE n=25 (3.7%) n=30 (9.3%) n=59 (18.2%) n=40 (23.3%)
 Model 1 1 (Reference) 1.65 (0.97 to 2.81) 2.65 (1.64 to 4.27) 4.20 (2.51 to 7.02)
 Model 2 1 (Reference) 1.52 (0.89 to 2.59) 2.41 (1.48 to 3.91) 3.82 (2.27 to 6.43)
 Model 3 1 (Reference) 1.52 (0.89 to 2.61) 2.38 (1.47 to 3.88) 3.79 (2.26 to 6.39)
 Model 4 1 (Reference) 1.68 (0.97 to 2.92) 2.31 (1.39 to 3.84) 3.27 (1.88 to 5.70)
Coronary event n=14 (2.1%) n=17 (5.3%) n=41 (12.7%) n=27 (15.7%)
 Model 1 1 (Reference) 1.69 (0.83 to 3.44) 3.39 (1.82 to 6.29) 5.23 (2.7 to 10.14)
 Model 2 1 (Reference) 1.61 (0.78 to 3.29) 3.25 (1.74 to 6.07) 5.5 (2.84 to 10.64)
 Model 3 1 (Reference) 1.57 (0.76 to 3.22) 3.09 (1.65 to 5.79) 5.14 (2.65 to 9.98)
 Model 4 1 (Reference) 1.42 (0.71 to 2.89) 2.76 (1.44 to 5.31) 4.50 (2.26 to 9.02)
Stroke event n=11 (1.6%) n=13 (4.0%) n=20 (6.2%) n=17 (9.9%)
 Model 1 1 (Reference) 1.59 (0.71 to 3.57) 1.94 (0.91 to 4.14) 3.84 (1.75 to 8.43)
 Model 2 1 (Reference) 1.47 (0.65 to 3.29) 1.77 (0.83 to 3.79) 3.19 (1.42 to 7.16)
 Model 3 1 (Reference) 1.47 (0.65 to 3.31) 1.70 (0.79 to 3.66) 3.16 (1.41 to 7.10)
 Model 4 1 (Reference) 1.03 (0.50 to 2.09) 1.13 (0.57 to 2.14) 1.27 (0.69 to 2.62)
All-cause mortality n=8 (1.2%) n=7 (2.2%) n=16 (4.9%) n=21 (12.2%)
 Model 1 1 (Reference) 1.13 (0.41 to 3.14) 1.99 (0.83 to 4.76) 6.14 (2.61 to 14.46)
 Model 2 1 (Reference) 1.13 (0.41 to 3.14) 1.78 (0.73 to 4.35) 4.87 (1.99 to 11.88)
 Model 3 1 (Reference) 1.14 (0.41 to 3.16) 1.79 (0.73 to 4.38) 4.87 (1.99 to 11.88)
 Model 4 1 (Reference) 1.01 (0.40 to 1.15) 1.09 (0.43 to 2.76) 2.07 (1.05 to 3.01)

Models are defined as follows: model 1=adjusted for age and gender; model 2=adjusted for model 1 + presence of hypertension or diabetes mellitus, current smoking status, systolic blood pressure, postprandial blood glucose, total cholesterol, high-density lipoprotein cholesterol, antihypertensive medication use and antidiabetic medication use; model 3=adjusted for model 2 + estimated glomerular filtration rate; model 4=adjusted for model 3 + high-sensitivity C reactive protein and N-terminal pro-B-type natriuretic peptide (both after logarithmic transformation).

hs-cTnT, highly sensitive cardiac troponin T; MACE, major adverse cardiovascular event.