Table 1.

Proteins that interact with hypoxia-inducible factor 1α (HIF-1α).

Protein	Also known as	HIF-1α Residuesa	Other Partner (s):	Reference(s)
ARD1	NAA10	401–603		[3,4]
ARNT	HIF–1β	1–390		[1,2]
ARNTL	BMAL1, MOP3	ND		[5,6]
ARNTL2	BMAL2, MOP9	ND		[7]
ARRB1	Arrestin-β1	ND	p300	[8,9]
ATP6V0C		1–16		[10]
BCL2		ND	HSP90	[11]
BHLHE41	DEC2, SHARP1	ND	20S proteasome	[12]
BRG1	SMARCA4	ND		[13]
CBP	CREBBP	531–584, 786–826		[14–17]
CBX4	Chromobox 4	299–604	PRC1	[18]
C/EBPα	CEBPA	1–302		[19,20]
CDC6		1–329	MCMs	[21]
CDK1		ND		[22,23]
CDK2		ND		[23]
CDK5		ND		[24,25]
CDK8		ND	Mediator	[26]
CJUN (non-phospho)		345–787		[27,28]
CK1δ		PAS-Bb		[29]
COMMD1		1–300	HSP70	[30,31]
CRM1		616–658		[32]
CTNNB1	β-catenin	1–344		[33]
DROSHA		ND		[34]
E2F7		1–80		[35]
EAF2		(HIF–1α only)c	VHL	[36]
ERα	ESR1	ND		[37]
ERK1/2	MAPK3/1	616–658		[32]
ERRα,β,γ	ESRRA/B/G	HIF-α: HIF–1β	SRC–1/2; PGC–1α/β	[38,39]
ETV4		786–826		[40]
FBP1		604–786		[41]
FHL2		429–608		[42]
FIH–1		757–826	VHL	[43]
FLNA		(HIF–1α only)		[44]
FOXA2		1–390	p300	[45]
FOXP3		ND	VHL	[46]
GR	NR3C1	85–153, 238–346		[47]
GPD1L		ND		[48]
GSK3β	GSK3B	ND		[49]
HAF	SART1	298–400		[50,51]
HBV X		1–400		[52]
HDAC1		ODD		[53]
HDAC3		ODD		[53]
HDAC4		ND		[54,55]
HDAC6		ND		[54]
HDAC7		601–785		[56]
HDM2	MDM2	bHLH; 776–826	p53	[57]
HEXIM1		ND		[58]
HHV–8 vIRF		bHLH		[59]
HNF4		106–526		[60]
HPV E7		ND	excludes HDACs	[61]
HSPA8	HSC70	1–329; 529NEFKL	CHIP, LAMP2A	[62,63]
HSP70		331–427	CHIP	[64]
HSP90		81–200		[65]
Importin 7		bHLH-PAS-A		[66]
ING1b	ING	ND		[67]
IRF1		ND		[68]
JAB1	COPS5, CSN5	401–603		[69]
JMJD2C	KDM4C	575–786		[70]
KAT5	TIP60	ND		[71]
KDM1A	LSD1	ND		[72,73]
KSHV LANA		300–530		[74]
KSHV vIRF		ND		[75]
LAMP2A		ND	HSC70	[62]
MAX		ND		[76]
MCM2		ND		[77]
MCM3		531–826		[77]
MCM5		ND		[77]
MCM7		201–329	VHL, Elongin C	[77]
MGCRACGAP		ND		[78]
MTA1		401–603; 576–785; 786–826	HDAC1	[79]
MUC1		ND	p300	[80]
MYC		1–329		[81]
NBS1		1–400		[82]
NECDIN		ODD		[83]
NEMO		ND	IKKβ	[84]
NOTCH		ND		[85]
NOTCH3		ND		[86]
NQO1		331–575		[87]
OS-9		692–826	PHD2, PHD3	[88]
OTUD7B		ND		[89]
P14ARF		1–199, 463–452		[90]
P16		ND		[91]
P53	TP53	1–330		[92–94]
P300		786–826		[95,96]
PARP1		ND (HIF-–1α and HIF-2α)		[97,98]
PCAF		ND		[99]
PER1		ND		[100]
PER2		ND		[101]
PHD1		ND		[88,102]
PHD2		531–610	OS-9	[88,102]
PHD3		531–826	OS-9	[88,102]
PIASY		211–330, 331–698 (phosphorylated HIF–1α)		[104]
PIN1				[105]
PKM2		81–200; 201–329; 331–427;575–786	PHD3	[106]
PLD1		1–401	PHD2	[107]
PLK3		ND		[108]
PONTIN		ND	p300	[109]
PRDX1		ND		[110]
PRDX2		575–786		[110]
PRDX4		531–826		[110]
PRDX6		ND		[110]
PRKACA		1–200; 531–826	PRKAR1A	[111]
PS1-NTF		1–364	PS1-CTF/Aph1a, Nct, Pen2	[112]
PSMA7		726–785		[113]
RACK1	GNB2L1	81–200	Elongin C, RHBDF1	[114]
RAPTOR		ND		[115]
RB		530–694		[116]
REF-1		531–584, 776–826		[14]
REPTIN		ND	HDAC1	[117]
RHOBTB3		ND	PHD2, VHL, LIMD1	[118]
RND3	RHOE	ND		[119]
RON		ND		[120]
RSUME		ND	UBC9, VHL	[121,122]
RUNX1	AML1	ND		[123]
RUNX2		ODD		[124]
RUNX3		603–826	PHD2	[125]
SENP1		ODD		[126]
SEPT9_V1	SEPT9	HLH (HIF-1α only)	comp RACK1	[127,128]
SET7		1–80, 201–330, 400–575, 576–785		[71,129]
SIRT1		600–826		[99,130]
SIRT2		ND		[131]
SIRT6		ND		[132]
SIRT7		ND		[133]
SMAD3		ND		[134]
SP1		PAS-B		[81,135]
SPRY2		ND	VHL	[136]
SRC-1		776–826		[14]
SSAT1		201–329	RACK1	[137]
SSAT2		81–200	VHL, Elongin C	[138]
STAT3		(HIF-1α only)	CBP, P300	[139]
STUB1	CHIP	201–329	HSP70	[64]
SUMO-1		ND		[140]
TAp63		ND		[141]
TAp73		1–330	MDM2	[142]
TAZ		ND		[143]
TIF2		ND		[14]
TRAF6		ND		[144]
TSGA10		1–401(mHIF-1α I.2);PAS-B;TAD-C		[145,146]
UCHL1		ND		[147]
USP7	HAUSP	ND		[148]
USP8		ND		[149]
USP19		bHLH-PAS	SIAH1, SIAH2	[150]
VDU2	USP20	ND		[151]
VHL		402+ND; 549–582		[152]
WWOX		ND		[153]
XBP1s		(HIF-1α only)		[154]
YAP		ND		[155]
YY1		ND		[156]

^aND, not determined.

^bIn some papers, interacting proteins were shown to bind to truncated recombinant proteins containing only a certain domain or subdomain within HIF-1α (e.g. bHLH-PAS, ODD, or PAS-B) but the specific amino acid residues were not stated.

^cHIF-2α was tested and did not bind to the HIF-1α-interacting protein.