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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: Exp Cell Res. 2017 Mar 20;356(2):128–135. doi: 10.1016/j.yexcr.2017.03.041

Table 2.

Interacting proteins that stimulate O2- and PHD/VHL-dependent degradation of HIF-1α.

Protein Mechanism of action Reference
HEXIM1 Increased hydroxylation [58]
MCM7 Increased ubiquitination [77]
OS9 Increased hydroxylation [88]
PLD1 Increased hydroxylation [107]
RHOBTB3 Increased hydroxylation [118]
RUNX3 Increased hydroxylation [125]
SIRT2 Increased hydroxylation [131]
SPRY2 Increased ubiquitination [136]
SSAT2 Increased ubiquitination [138]
WWOX Increased hydroxylation [153]