. Author manuscript; available in PMC: 2018 Jul 15.

Published in final edited form as: Exp Cell Res. 2017 Mar 20;356(2):128–135. doi: 10.1016/j.yexcr.2017.03.041

Table 3.

Interacting proteins that inhibit O₂-dependent degradation of HIF-1α.

Protein	Mechanism of action	Reference
ATP6V0C	Competes with VHL for binding	[10]
NQO1	Competes with PHDs for binding	[87]
OTUD7B	Mediates deubiquitination of HIF-1α	[89]
RSUME	Inhibits VHL-E3 ligase complex	[122]
RUNX2	Competes with VHL for binding	[124]
SENP1	Mediates deSUMOylation of HIF-1α	[126]
UCHL1	Mediates deubiquitination of HIF-1α	[147]
USP8	Mediates deubiquitination of HIF-1α	[149]
USP20	Mediates deubiquitination of HIF-1α	[151]