. Author manuscript; available in PMC: 2018 Jul 15.

Published in final edited form as: Exp Cell Res. 2017 Mar 20;356(2):128–135. doi: 10.1016/j.yexcr.2017.03.041

Table 4.

Interacting proteins that mediate O₂-independent degradation of HIF-1α.

Protein	Mechanism of action	Reference
BHLHE41	Interaction with proteasome	[12]
CDK2	Chaperone-mediated autophagy	[23]
CHIP/HSP70	Ubiquitination	[64]
CHIP/HSC70/LAMP2A	Chaperone-mediated autophagy	[62,63]
HAF	Ubiquitination	[50,51]
P53	MDM2-dependent ubiquitination	[94]
PIASY	SUMOylation	[104]
RACK1	Ubiquitination	[114]
SIRT1	ND	[130]
SIRT7	Proteasome/lysosome-independent degradation	[133]
SSAT1	RACK1-dependent ubiquitination	[137]
TAp73	MDM2-dependent ubiquitination	[142]