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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: Exp Cell Res. 2017 Mar 20;356(2):128–135. doi: 10.1016/j.yexcr.2017.03.041

Table 5.

Interacting proteins that inhibit O2-independent degradation of HIF-1α.

Protein Mechanism of action Reference
BCL2 Inhibits ubiquitination by stabilizing HSP90 binding [11]
CDK1 Inhibits chaperone-mediated autophagy [22,23]
HSP90 Inhibits ubiquitination by RACK1 [65,114]
MUC1 Not determined [80]
SEPT9 Inhibits ubiquitination by RACK1 [127,128]
TRAF6 Stabilizes HIF-1α via K63-linked polyubiquitination [144]