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. Author manuscript; available in PMC: 2018 Jul 15.
Published in final edited form as: Exp Cell Res. 2017 Mar 20;356(2):128–135. doi: 10.1016/j.yexcr.2017.03.041

Table 6.

Interacting proteins that regulate transactivation by HIF-1α.

Protein Mechanism of action Reference
CBP Coactivator; binds to non-hydroxylated C-terminal TADa [1417]
COMMD1 Blocks HIF-1α: HIF-1β heterodimerization [21,22]
EAF2 Disrupts interaction of CBP/p300 with HIF-1α [36]
FBP1 Co-repressor; inhibits C-terminal TAD [41]
FHL2 Co-repressor [42]
FIH-1 Hydroxylates N803 to block binding of CBP/p300 [43,157]
JMJD2C Coactivator; demethylates H3K9me3b at HREsc [70]
KAT5 Coactivator; required for RNA Pol II activation [71]
MCM7 Inhibits transactivation in a hydroxylation manner [77]
MGCRACGAP Blocks HIF-1α: HIF-1β heterodimerization [78]
MUC1 Stabilizes interaction of p300 with HIF-1α [80]
P300 Coactivator; binds to non-hydroxylated C-terminal TADb [95,96]
PARP1 Coactivator [97,98]
PCAF Coactivator; enhances p300 recruitment [99]
PKM2 Coactivator; enhances HIF-1 binding, p300 recruitment [106]
PONTIN Coactivator; increases recruitment of p300 [109]
REPTIN Recruits HDAC1 to a subset of HIF target genes [117]
SET7 Blocks binding of HIF-1 to DNA [71,129]
SIRT1 Deacetylates HIF-1α on K674 to inhibit p300 binding [99]
SIRT6 Co-repressor [132]
SRC1 Co-activator [14]
STAT3 Co-activator [139]
TAZ Co-activator; increases HIF-1α binding to HREs [143]
TIF2 Co-activator [14]
TSGA10 Blocks nuclear localization [145,146]
XBP1s Co-activator; increases RNA Pol II recruitment [154]
a

TAD, transactivation domain.

b

H3K9me3, histone 3, trimethylated on lysine 9.

c

HREs, hypoxia response elements.