Table 6.
Protein | Mechanism of action | Reference |
---|---|---|
CBP | Coactivator; binds to non-hydroxylated C-terminal TADa | [14–17] |
COMMD1 | Blocks HIF-1α: HIF-1β heterodimerization | [21,22] |
EAF2 | Disrupts interaction of CBP/p300 with HIF-1α | [36] |
FBP1 | Co-repressor; inhibits C-terminal TAD | [41] |
FHL2 | Co-repressor | [42] |
FIH-1 | Hydroxylates N803 to block binding of CBP/p300 | [43,157] |
JMJD2C | Coactivator; demethylates H3K9me3b at HREsc | [70] |
KAT5 | Coactivator; required for RNA Pol II activation | [71] |
MCM7 | Inhibits transactivation in a hydroxylation manner | [77] |
MGCRACGAP | Blocks HIF-1α: HIF-1β heterodimerization | [78] |
MUC1 | Stabilizes interaction of p300 with HIF-1α | [80] |
P300 | Coactivator; binds to non-hydroxylated C-terminal TADb | [95,96] |
PARP1 | Coactivator | [97,98] |
PCAF | Coactivator; enhances p300 recruitment | [99] |
PKM2 | Coactivator; enhances HIF-1 binding, p300 recruitment | [106] |
PONTIN | Coactivator; increases recruitment of p300 | [109] |
REPTIN | Recruits HDAC1 to a subset of HIF target genes | [117] |
SET7 | Blocks binding of HIF-1 to DNA | [71,129] |
SIRT1 | Deacetylates HIF-1α on K674 to inhibit p300 binding | [99] |
SIRT6 | Co-repressor | [132] |
SRC1 | Co-activator | [14] |
STAT3 | Co-activator | [139] |
TAZ | Co-activator; increases HIF-1α binding to HREs | [143] |
TIF2 | Co-activator | [14] |
TSGA10 | Blocks nuclear localization | [145,146] |
XBP1s | Co-activator; increases RNA Pol II recruitment | [154] |
TAD, transactivation domain.
H3K9me3, histone 3, trimethylated on lysine 9.
HREs, hypoxia response elements.