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. 2017 Aug 2;13:229. doi: 10.1186/s12917-017-1151-z

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© The Author(s). 2017

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Effects of PEA-Q on MIA-induced histological features of OA knee tissue. Histological evaluation was performed by haematoxylin and eosin staining. Panel (a), sham; panel (b), MIA–injected; Panels (c) and (d), PEA-Q treatment; Panels d and (e), meloxicam treatment. Figures are representative of all animals in each group. Panel (f), Mankin score for the various treatment groups. Values are means ± SEM of 10 animals for each group. ***p < 0.0001 vs sham. ^### p < 0.0001 vs MIA + vehicle. °p < 0.05 vs MIA + PEA-Q (10 mg/kg) and MIA + meloxicam