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. Author manuscript; available in PMC: 2018 Jun 7.
Published in final edited form as: Nature. 2017 Jun 7;546(7657):234–242. doi: 10.1038/nature22379

Figure 3. Metabolic Control by the mTORC1 Signalling Pathway.

Figure 3

Full activation of mTORC1 kinase requires concerted inputs from growth factor signalling and intracellular amino acids. Once active, mTORC1 enhances cell growth by promoting protein translation as well as biosynthesis of lipids and nucleotides. mTORC1 also increases cell surface amino acid transporter levels, but suppresses lysosomal catabolism of proteins derived from endocytosis or autophagy, thereby rendering cells dependent on availability of free amino acids.