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NIs in the Peripheral Nerve. (A) General overview of peripheral nerve anatomy. Individual axons are bundled in endoneurium and in turn, into discrete fascicles, supplied via blood vessels embedded in the perineurium. Fascicles in turn are bundled and protected by the dense connective tissue of the epineurium. (B) Peripheral interface electrodes range from extraneural (upper left), to penetrating/intraneural (upper right), to regenerative (bottom).
