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. 2001 Jul 24;98(16):9312–9317. doi: 10.1073/pnas.161102498

Figure 1.

Figure 1

A model for Notch involvement in T-lymphoid development (modified from ref. 33). Notch signaling in lymphoid precursor cells in the bone marrow and/or in the thymus favors T-lymphoid over B-lymphoid differentiation. Notch also appears to bias the early differentiation of double-negative (DN) T cell precursors toward the αβ T cell lineage. Finally, Notch promotes positive selection of double-positive (DP) to single-positive (SP) cells with a predominant effect on the selection and/or survival of CD8 cells (see text for details and references).