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. 2017 Jul 3;6(7):e354. doi: 10.1038/oncsis.2017.56

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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VEGF-C protein expression levels and regulation in CAL33 cells following P or X irradiation. (a) VEGF-C protein levels at 48 h post-single irradiation (AR-SI): * and *, significantly (P<0.05) increased levels after a low (2 Gy) or high (8 Gy) dose of P and X irradiation, respectively, as compared to CT; #, significantly decreased levels after a high dose of P, as compared to X irradiation; §, significantly increased levels after a high, as compared to a low X irradiation dose; (b) VEGF-C protein levels after cell expansion following the third irradiation (CR-MI): * and *, significantly increased levels after low and high doses of P and X irradiation, respectively, as compared to CT; Concentration in ng/ml, normalized to 1 × 10⁶ cells, and represented as percentage of CT. #, significantly decreased levels after high doses of P, as compared to X irradiation; §, significantly increased levels after high, as compared to low doses of X irradiation; (c) Activity of a short vegf-c promoter (CR-MI); (d) Activity of an artificial promoter having three binding sites for NF-kB (CR-MI); (e) Activity of a VEGF-C 3′UTR reporter gene (CR-MI). * and *, significantly (P<0.05) increased promoter activity after P and X irradiation, respectively, as compared to CT; # and #, significantly decreased activity of MUT, as compared to WT vegf-c promoter after P and X irradiation, respectively; §, significantly decreased promoter activity after P, as compared to X irradiation. CT, control (non-irradiated cells); MUT, mutated, WT, wild type.