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. 2017 Jul 10;6(7):e356. doi: 10.1038/oncsis.2017.59

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Copyright © 2017 The Author(s)

Oncogenesis is an open-access journal published by Nature Publishing Group. This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Metabolic analysis upon MeCP2 depletion or DNMTs inhibition. (a–c) Relative changes in glutamine consumption (a), α-KG production (b) and intracellular ATP content (c) in HCT116 cells upon MeCP2 depletion. Mean±s.d. (n=3), t-test; *P<0.05. (d–f) Relative changes in glutamine consumption (d), α-KG production (e) and intracellular ATP content (f) in HCT116 upon DNMTs inhibition. Mean±s.d. (n=3), t-test; *P<0.05. (g) A simplified model depicting ASCT2 regulation by miR-137. See text for more details.