Table 3.
Effects of 7-methoxycoumarin (MC) and F. umbellata aqueous extract on estrogen target organs and lipids profile on postmenopausal-rat model after 21 days treatment
| Ovariectomized rats | ||||||
|---|---|---|---|---|---|---|
| Items | SHAM | OVX | E2V | FU 50 | FU 200 | MC |
| Estrogen target organs | ||||||
| Uterine wet weight (mg/kg) | 1921.36±185.26 | 356.9±19.05### | 1288.42±136.9*** | 546.12±44.24 | 349.69±7.69 | 409.83±15.81 |
| Uterine epithelial height (μm) | 6.71±0.36 | 3.06±0.16### | 5.27±0.15*** | 3.6±0.37 | 3.84±0.18 | 3.39±0.20 |
| Vaginal epithelial height (μm) | 19.06±0.11 | 2.54±0.56### | 14.25±0.55*** | 6.24±0.20** | 7.86±0.01** | 8.56±1.39*** |
| Lipids profile | ||||||
| Total cholesterol level (mg/dL) | 67.92±6.27 | 93.9±2.29## | 56.98±11.27* | 83.01±10.27 | 56.53±4.99* | 79.24±11.67 |
| Triglycerides levels (mg/dL) | 47.96±3.75 | 62.96±7.35# | 44.66±2.02* | 63.01±6.46 | 49.48±1.67 | 56.08±4.26 |
| HDL-Cholesterol level (mg/dL) | 46.62±0.91 | 44.91±0.34# | 45.94±0.54* | 45.1±0.38 | 45.60±0.66* | 45.33±0.44 |
| Atherogenic risk | 1.28±0.20 | 1.63±0.15# | 1.19±0.15* | 1.84±0.22 | 1.19±0.21 * | 1.69±0.22 |
SHAM = Sham operated rats treated with vehicle as normal control; OVX = Ovariectomized rats treated with vehicle as negative control; E2V = Ovariectomized rats treated with estradiol valerate at the dose of 1 mg/kg BW; FU 50 and 200 = Ovariectomized rats treated with F. umbellata aqueous extract at the doses of 50 and 200 mg/kg BW, respectively; MC = Ovariectomized rats treated with 7-methoxycoumarin at the dose of 1 mg/kg BW. # p <0.05, ## p < 0.01, ### p <0.001 as compared to SHAM group. *p <0.05, **p < 0.01, ***p <0.001 as compared to OVX group