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. 2001 Jul 17;98(16):9318–9323. doi: 10.1073/pnas.161204098

Figure 3.

Figure 3

i.n. immunization with protein σ1-PL-pCMVLuc enhances AFC responses when compared with immunizations with naked pCMVLuc. Mice received 3 doses of protein σ1-PL-pCMVLuc or pCMVLuc, and were assessed for AFC responses in mucosal and systemic tissues by Luc-specific ELISPOT 6 weeks after the first dose. (A) IgA AFCs were significantly elevated in NALT and small intestinal LP compared with the naked DNA immunization group. (B) IgG AFCs were elevated in NPs. Both IgG and IgA AFCs were minimally affected in spleen. Depicted is the mean of three experiments (± SD), and each experiment represents 5 mice per administration group. *, P ≤ 0.025; **, P < 0.001.