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. 2017 Jul 7;28(14):1815–1818. doi: 10.1091/mbc.E17-05-0320

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© 2017 Weaver. This article is distributed by The American Society for Cell Biology under license from the author(s). Two months after publication it is available to the public under an Attribution–Noncommercial–Share Alike 3.0 Unported Creative Commons License (http://creativecommons.org/licenses/by-nc-sa/3.0).

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FIGURE 1: — Mechanical force across length scales regulates cell behavior and tissue development. (Top left) Spindle forces are critical for cell division. (Top right) The stiffness of the extracellular matrix promotes focal adhesion assembly to modulate cell migration. (Bottom left) Cell–cell force dictates embryonic patterning. (Bottom right) Tissue-level forces modulate branching morphogenesis and when corrupted can foster cell invasion.