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. Author manuscript; available in PMC: 2018 May 24.
Published in final edited form as: Cell Syst. 2017 May 24;4(5):483–494. doi: 10.1016/j.cels.2017.04.006

Figure 2.

Figure 2

Putative Commander subunits. Recent human interaction networks describe overlapping pieces of the Commander complex. Three are experimentally derived and include a metazoan complex map (Wan et al., 2015, Drew et al., 2017), the ‘Bioplex’ network (Huttlin et al., 2015) and an interactome in ‘quantitative dimensions’ (Hein et al., 2015). Two are computational networks calculated using phylogenetic profiling (Dey et al., 2015) or ‘clustering by inferred models of evolution’ (CLIME) (Li et al., 2014). The 14 protein subunits identified by at least three studies are considered in this proposal as the strongest candidates to be core components of Commander (thick black line).