Putative Commander subunits. Recent human interaction networks describe overlapping pieces of the Commander complex. Three are experimentally derived and include a metazoan complex map (Wan et al., 2015, Drew et al., 2017), the ‘Bioplex’ network (Huttlin et al., 2015) and an interactome in ‘quantitative dimensions’ (Hein et al., 2015). Two are computational networks calculated using phylogenetic profiling (Dey et al., 2015) or ‘clustering by inferred models of evolution’ (CLIME) (Li et al., 2014). The 14 protein subunits identified by at least three studies are considered in this proposal as the strongest candidates to be core components of Commander (thick black line).