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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: JAMA Cardiol. 2017 Apr 1;2(4):419–428. doi: 10.1001/jamacardio.2016.5670

Figure 2. Spline Analysis for the Relationship Between Maximal LV Wall Thickness Z-Score and E′ Velocity, Exercise Capacity and Early Phenotypic Burden in Sarcomere Mutation Carriers.

Figure 2

A. Septal E′ velocity tended to worsen with increasing LV wall thickness but the association diminished beyond a maximal LV wall thickness z score of 10 (corresponding to an absolute LV wall thickness of ∼18 mm in the average adult).

B. Peak Mets achieved on exercise testing initially worsened, but beyond a maximal LV wall thickness z-score of 5.5 (absolute adult LV wall thickness of ∼13.5 mm), there is no change in exercise capacity with increasing LV wall thickness.

C. The burden of early phenotypic manifestations increases prominently with increasing LV wall thickness up to a maximal LV wall thickness z-score of 8 (absolute adult LV wall thickness of ∼16 mm) then shows little further incremental change.