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. Author manuscript; available in PMC: 2018 Apr 1.
Published in final edited form as: JAMA Cardiol. 2017 Apr 1;2(4):419–428. doi: 10.1001/jamacardio.2016.5670

Table 3. Prevalence of Early Phenotypic Abnormalities in Mutation Carriers and Controls.

G+/LVH+(n=81) G+/LVH-(N=55) Controls (n=42) G+/LVH+ vs G+/LVH- P-value G+/LVH+ vs Control P-value G+/LVH- vs Control P-value
LV Thickness:Diameter Ratio > 0.23 99% 35% 12% < 0.001 < 0.001 0.04
LVEDD z-score < -1.5 88% 68% 37% 0.002 < 0.001 0.009
Singulex Troponin I >3.0 pg/ml 73% 40% 20% 0.006 < 0.001 0.05
LVESD z-score < -1.5 72% 57% 30% 0.09 < 0.001 0.004
NTproBNP>100 pg/ml 58% 14% 8% < 0.001 < 0.001 0.45
QST Present on ECG 46% 14% 3% < 0.001 < 0.001 0.09
Septal E′ z-score < -1.5 42% 13% 5% < 0.001 0.002 0.17

QST, ECG Q waves or ST changes; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LV, left ventricular

P values and percentages were adjusted for patient age, sex, and familial relationships.

P values <0.017 are considered statistically significant, applying post hoc Bonferroni correction.