Table 3. Prevalence of Early Phenotypic Abnormalities in Mutation Carriers and Controls.

	G+/LVH+(n=81)	G+/LVH-(N=55)	Controls (n=42)	G+/LVH+ vs G+/LVH- P-value	G+/LVH+ vs Control P-value	G+/LVH- vs Control P-value
LV Thickness:Diameter Ratio > 0.23	99%	35%	12%	< 0.001	< 0.001	0.04
LVEDD z-score < -1.5	88%	68%	37%	0.002	< 0.001	0.009
Singulex Troponin I >3.0 pg/ml	73%	40%	20%	0.006	< 0.001	0.05
LVESD z-score < -1.5	72%	57%	30%	0.09	< 0.001	0.004
NTproBNP>100 pg/ml	58%	14%	8%	< 0.001	< 0.001	0.45
QST Present on ECG	46%	14%	3%	< 0.001	< 0.001	0.09
Septal E′ z-score < -1.5	42%	13%	5%	< 0.001	0.002	0.17

QST, ECG Q waves or ST changes; LVEDD, left ventricular end-diastolic dimension; LVESD, left ventricular end-systolic dimension; LV, left ventricular

P values and percentages were adjusted for patient age, sex, and familial relationships.

P values <0.017 are considered statistically significant, applying post hoc Bonferroni correction.