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. 2017 Jun 6;14(2):1309–1314. doi: 10.3892/ol.2017.6317

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Copyright: © Yin et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 5. — Effects of PV on the expression of Bcl-2, Bax and caspase-3 mRNA in TPC-1 and FTC-133 cell lines. (A) The mRNA level of Bcl-2 was decreased in TPC-1 and FTC-133 cell lines following treatment with PV at IC₅₀ at 37°C for 24 h. (B) The mRNA level of Bax was increased in TPC-1 and FTC-133 cell lines following treatment with PV at IC₅₀ for 24 h. (C) The mRNA level of caspase-3 was upregulated in TPC-1 and FTC-133 cell lines following treatment with PV at IC₅₀ for 24 h. Each bar represents mean ± standard deviation of three independent experiments. *P<0.05 vs. control group. B-cell lymphoma-2; Bax, Bcl-2 associated X protein; PV, Prunella vulgaris; IC₅₀, Half-maximal inhibitory concentration.